Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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286
Tocris Bioscience™ NIKi
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent NIK inhibitor
287
Tocris Bioscience™ EM 163
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TIR-TIR interaction inhibitor
290
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Ginsenoside Rg1, Thermo Scientific™
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Ginsenoside Rg1, Thermo Scientific™
CAS: 22427-39-0 Molecular Formula: C42 H72 O14 Molecular Weight (g/mol): 801.02 MDL Number: MFCD00210293 InChI Key: YURJSTAIMNSZAE-HHNZYBFYSA-N IUPAC Name: (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-3a,3b,6,6,9a-pentamethyl-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol SMILES: CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3[C@H](C[C@@]21C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
| CAS | 22427-39-0 |
|---|---|
| Molecular Weight (g/mol) | 801.02 |
| MDL Number | MFCD00210293 |
| SMILES | CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3[C@H](C[C@@]21C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |
| IUPAC Name | (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-3a,3b,6,6,9a-pentamethyl-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChI Key | YURJSTAIMNSZAE-HHNZYBFYSA-N |
| Molecular Formula | C42 H72 O14 |
292
Tocris Bioscience™ PAG 3'-fluoro-4'-piperazine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Functionalized cereblon ligand for PROTAC development
294
Tocris Bioscience™ Phen Green SK diacetate
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Heavy metal ion indicator, membrane permeable
295
296
Tocris Bioscience™ CST 967
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Potent and selective USP7 Degrader (PROTAC™)
297
Tocris Bioscience™ WQ 1
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Potent and selective σ1 receptor antagonist; active in vivo
| Target | Sigma1 Receptor Antagonists |
|---|---|
| CAS | 1204401-49-9 |
| Purity | 0.98 |
| Chemical Name or Material | 2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4 H-1-benzothiopyran-4-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C21H23NOS |
298
Tocris Bioscience™ GT 949
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Potent and selective positive allosteric modulator of EAAT2
| CAS | 460330-27-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C30H37N7O2 |
299
Tocris Bioscience™ CPS2
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Potent and selective CDK2 Degrader (PROTAC™)
300
Tocris Bioscience™ NFκB p50 Transcription Factor Assay
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The transcription factor NFkB is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response