Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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286
Tocris Bioscience™ SJ 1008066
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
287
Tocris Bioscience™ PAG 3'-piperazine-4-methylpiperidine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cereblon ligand with terminal piperidine for onward chemistry
288
Tocris Bioscience™ BRD 0539
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cell permeable and reversible Cas9 inhibitor
| Target | CRISPR Reagents |
|---|---|
| CAS | 1403838-79-8 |
| Purity | 0.98 |
| Chemical Name or Material | (3 aR,4 R,9 bR)-8-(2-Fluorophenyl)-2,3,3 A,4,5,9 b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1 H-pyrrolo[3,2-c]quinoline-4-methanol |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C25H25FN2O3S |
289
| CAS | 39809-25-1 |
|---|---|
| Molecular Formula | C10H15N5O3 |
290
Tocris Bioscience™ ARN 11391
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potentiator of the IP3-gated calcium channel ITPR1
| Target | IP3R1 |
|---|---|
| CAS | 1214569-31-9 |
| Purity | 0.98 |
| Chemical Name or Material | 2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2 H-pyran-2-yl)methoxy]phenyl]-2 H-indazole-3-carboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C22H29N3O3 |
292
Invitrogen™ A-23187 Free Acid (Calcimycin)
Commonly used for in situ calibrations of fluorescent Ca2+ indicators
Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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293
Tocris Bioscience™ RP 6306
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective PKMYT1 inhibitor
| Target | Cyclin-dependent Kinase Inhibitors |
|---|---|
| CAS | 2719793-90-3 |
| Purity | 98% |
| Chemical Name or Material | (S)-2-Amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethylpyrrolo[2,3-b]pyridine-3-carboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H20N4O2 |
294
Thermo Scientific Chemicals T0901317, 95%
CAS: 293754-55-9 Molecular Formula: C17H12F9NO3S Molecular Weight (g/mol): 481.33 InChI Key: SGIWFELWJPNFDH-UHFFFAOYSA-N IUPAC Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide SMILES: OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F
| CAS | 293754-55-9 |
|---|---|
| Molecular Weight (g/mol) | 481.33 |
| SMILES | OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F |
| IUPAC Name | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide |
| InChI Key | SGIWFELWJPNFDH-UHFFFAOYSA-N |
| Molecular Formula | C17H12F9NO3S |
295
Tocris Bioscience™ ST 045849
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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O-GlcNAc transferase (OGT) inhibitor
| CAS | 442665-87-4 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid |
| Molecular Formula | C23H27ClN2O3S |
297
Tocris Bioscience™ JHU 37152
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
| Target | DREADD Activators |
|---|---|
| CAS | 2369979-67-7 |
| Purity | 0.98 |
| Chemical Name or Material | 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine |
| Recommended Storage | Store at RT |
| Molecular Formula | C19H20ClFN4 |
298
Tocris Bioscience™ Mpro Tracer
Greener Choice
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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SARS-CoV-2 main protease fluorescent ligand; TR-FRET acceptor
299
Tocris Bioscience™ ZNL 02-096
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective Wee1 Degrader (PROTAC™)
300
Tocris Bioscience™ CBR-470-1
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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PGK1 inhibitior; activates Nrf2
| Target | Nrf2 Activators |
|---|---|
| CAS | 2416095-06-0 |
| Purity | 98% |
| Chemical Name or Material | (3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C14H20ClNO4S2 |